PRC2 - Wikipedia
PRC2 is required for initial targeting of genomic region (PRC Response Elements or PRE) to be silenced, while PRC1 is required for stabilizing this silencing and underlies cellular memory of …
Role of the Polycomb Repressive Complex 2 (PRC2) in …
PRC2 is involved in establishing and maintaining gene expression patterns and, in turn, cell fates. Activating and inactivating mutations in genes encoding PRC2 contribute to human cancers, …
An evolving landscape of PRC2–RNA interactions in chromatin
Apr 30, 2025 · A major unsolved problem in epigenetics is how RNA regulates Polycomb repressive complex 2 (PRC2), a complex that trimethylates histone H3 Lys27 (H3K27me3) to …
Polycomb Repressive Complex 2 - an overview - ScienceDirect
The Polycomb Repressive Complex 2 (PRC2) is one of the classes of Polycomb-group proteins (PcG) which are transcriptional repressors with a crucial function in the maintenance of cell …
Polycomb repressive complex 2 (PRC2) pathway’s role in
Mar 6, 2025 · PRC2’s role extends beyond gene repression, as it contributes to metabolic reprogramming in tumors, regulating glycolysis and lipid synthesis to fuel cancer growth. …
The Arabidopsis PRC2 subunit MSI1 interacts with HY5 to repress ...
3 days ago · The Arabidopsis PRC2 subunit MSI1 partners with HY5 to epigenetically repress hypocotyl elongation via H3K27 tri-methylation during photomorphogenesis.
Pharmacological Advancements of PRC2 in Cancer Therapy: A
Dec 11, 2024 · Polycomb repressive complex 2 (PRC2) is known to regulate gene expression and chromatin structure as it methylates H3K27, resulting in gene silencing. Studies have shown …
Structural basis for inactivation of PRC2 by G-quadruplex RNA
Sep 21, 2023 · Polycomb repressive complex 2 (PRC2), an epigenetic gene-silencing complex that is essential for cell differentiation and is often deregulated in cancers, is a prominent …
PRC2, Chromatin Regulation, and Human Disease: Insights From …
Jun 21, 2022 · Here, we review the current knowledge on mechanisms of cellular regulation of PRC2 function, particularly regarding H3K27 methylation and chromatin targeting. PRC2 …
Frontiers | PRC2, Chromatin Regulation, and Human Disease: …
Jun 21, 2022 · Here, we review the current knowledge on mechanisms of cellular regulation of PRC2 function, particularly regarding H3K27 methylation and chromatin targeting. PRC2 …