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Vyjuvek is the first FDA-approved topical gene therapy and the first treatment for DEB (approved in 2023). It uses a modified/stripped version of the HSV virus to carry the instructions for collagen VII to the cells of the wound bed so that they can produce the collagen as the skin heals. I first used in 2023/2024 after a hand surgery and found it really helpful for healing my hand but not as helpful for other chronic/recurrent wounds. I decided to restart it again after my recent surgery on my
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